Lectins are proteins that bind to carbohydrates. Plant-derived lectins cause inflammatory diseases despite inconclusive evidence in some studies. The purpose of this study was to assess whether lectins cause inflammation. Foods with high doses of lectins have shown inflammation causing diseases including; Inflammatory Bowel Syndrome, Type 1 Diabetes, Rheumatoid Arthritis, and celiac. The data collected is measured on plant-based lectins resistant to digestion. A diet consisting of large amounts of vegetables is likely to result in an increase of dietary lectins. The earliest reporting of lectins causing inflammatory symptoms dated back to 1889 in the kidney bean, the data has shown the presence of high levels in phytohaemagglutinins. Chemical intoxication requires an adequate heat process for better digestion in the gut microbiome. Low doses of lectins may lead to the stimulation of inflammation in the body and have a major influence on the metabolism altering the bacterial cell in the bowel.  Although there is inconclusive evidence on the level of toxicity from lectins, the 5 studies on these plant proteins indicate the activation of NLRP3 inflammasome leading to inflammatory diseases. The results of the studies have shown a favorable outcome of minimizing symptoms of inflammatory diseases by proper food preparation and complete elimination of dietary lectins.