Survival is the necessity in life and learning and memory are key factors. A variety of diseases can deteriorate cognitive function including Alzheimer’s disease (AD). Coenzyme Q10 (CoQ10) is a supplement being used in patients with cognitive disorders. CoQ10 has shown effective in slowing the progression of Alzheimer’s disease. Oxidative stress and mitochondrial damage are the results of patients suffering from cognitive impairment, and CoQ10 is being used as a therapeutic intervention by mediating the triggering of neurodegeneration. The use of CoQ10 has been used in numerous trials and is a proven therapeutic interventional for neurodegenerative diseases such as Alzheimer’s disease. CoQ10 is a dynamic vitamin used within the diet to play significant roles including the respiratory process, controls fluid membrane, oxidative stress, and blood coagulation. As individuals age, there becomes a deficiency causing a variety of cardiovascular and neurological diseases. The studies in this research suggest Coenzyme Q10 is essential to control brain health and slow the progression of neurodegenerative diseases. More research has been done in the past decade on supplementing Coenzyme Q10 for the delay of neurodegenerative diseases than ever before. The trials reviewed in this study show the longer the therapy the more beneficial to delay cognitive impairment. The reduction of oxidative stress is a common denominator amongst the review and using therapeutic Coenzyme Q10 to generate more free radicals to lessen the symptoms of Alzheimer’s, Huntington’s, and Parkinson’s disease.